Rab GTPases in vesicular transport

Curr Opin Cell Biol. 1993 Aug;5(4):613-20. doi: 10.1016/0955-0674(93)90130-i.


Specificity and directionality are two features shared by the numerous steps of membrane transport that connect cellular organelles. By shuttling between specific membrane compartments and the cytoplasm, small GTPases of the Rab family appear to regulate membrane traffic in a cyclical manner. The restriction of certain Rab proteins to differentiated cell types supports a role for these GTPases in defining the specificity of membrane trafficking.

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • GTP Phosphohydrolases / metabolism*
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Membranes / metabolism
  • Organelles / metabolism
  • Substrate Specificity


  • GTP Phosphohydrolases
  • GTP-Binding Proteins