The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of apomorphine to the dopamine receptors. The effects of thymoleptics on elements of animal behavior that can be associated with brain dopamine appear interesting on the background of a considerable body of evidence indicating an association of brain dopamine with depression and mania (references).