5-hydroxytryptamine 3-receptor antagonist modulates gallbladder emptying and motilin release induced by erythromycin

Dig Dis Sci. 1993 Dec;38(12):2236-40. doi: 10.1007/BF01299902.


In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced gallbladder emptying and motilin release, as well as gallbladder emptying induced by a regular meal in healthy volunteers. Gallbladder emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P < 0.001 by ANOVA) the gallbladder emptying induced by 2 mg/kg/hr erythromycin, but did not increase basal gallbladder volume or inhibit gallbladder emptying induced by a regular meal. Ondansetron also inhibited the motilin release induced by erythromycin (P < 0.001, by ANOVA). These results suggest that serotoninergic mechanisms modulate the effects of erythromycin on the gastrointestinal tract. The exact site of action of ondansetron remains to be identified.

MeSH terms

  • Adult
  • Erythromycin / adverse effects
  • Erythromycin / antagonists & inhibitors
  • Erythromycin / pharmacology
  • Female
  • Food
  • Gallbladder Emptying / drug effects*
  • Humans
  • Male
  • Motilin / drug effects*
  • Motilin / metabolism
  • Ondansetron / adverse effects
  • Ondansetron / pharmacology*
  • Serotonin Antagonists*


  • Serotonin Antagonists
  • Ondansetron
  • Motilin
  • Erythromycin