Fat overload with a 10% soybean oil emulsion

Arch Surg. 1976 Dec;111(12):1391-3. doi: 10.1001/archsurg.1976.01360300081013.


A 10% soybean oil emulsion (Intralipid) has been demonstrated to be an effective means of delivering an adequate caloric intake via a peripheral vein. This emulsion has generally been considered safe and free of significant complications. This is a report of a child who initially thrived on this intravenously administered fat emulsion, then suddenly developed a lifethreatening intolerance to the infusion, which appeared to be the "fat overload syndrome." This syndrome, seen frequently with earlier fat emulsions, has not been reported previously as a complication of the 10% soybean oil emulsion.

Publication types

  • Case Reports

MeSH terms

  • Dietary Fats / adverse effects*
  • Emulsions
  • Glycine max / adverse effects*
  • Hepatomegaly / etiology
  • Humans
  • Hyperlipidemias / etiology
  • Infant
  • Male
  • Parenteral Nutrition / adverse effects*
  • Splenomegaly / etiology
  • Syndrome


  • Dietary Fats
  • Emulsions