A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

Gene. 1993 Dec 8;134(2):295-8. doi: 10.1016/0378-1119(93)90110-o.

Abstract

A 1.4-kb full-length cDNA was isolated from a library constructed from activated human T-cell leukemia virus type 1-transformed human T-lymphocytes. Sequence analysis identified this cDNA as a new member of the human nerve-growth-factor receptor/tumor-necrosis-factor receptor family and as the potential human homologue of the murine sequence, 4-1BB. The gene encodes three cysteine-rich motifs in the extracellular domain which are characteristic of this receptor family, a transmembrane region and a short N-terminal cytoplasmic portion which contains potential phosphorylation sites.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA
  • Humans
  • Lymphocyte Activation*
  • Mice
  • Molecular Sequence Data
  • Receptors, Cytokine / analysis
  • Receptors, Cytokine / genetics*
  • Receptors, Nerve Growth Factor / genetics
  • Receptors, Tumor Necrosis Factor / genetics
  • Sequence Homology, Amino Acid
  • T-Lymphocytes / chemistry
  • T-Lymphocytes / immunology*

Substances

  • ILA receptor
  • Receptors, Cytokine
  • Receptors, Nerve Growth Factor
  • Receptors, Tumor Necrosis Factor
  • DNA

Associated data

  • GENBANK/L12964
  • GENBANK/L24529
  • GENBANK/X72887
  • GENBANK/X72985
  • GENBANK/X72986
  • GENBANK/X72987
  • GENBANK/X72988
  • GENBANK/X72989
  • GENBANK/Z15047
  • GENBANK/Z15048