The sites of origin of serotoninergic afferent fibers in the trigeminal motor, facial, and hypoglossal nuclei in the rat

Neurosci Res. 1993 Sep;17(4):307-13. doi: 10.1016/0168-0102(93)90114-6.

Abstract

The sites of origin of serotoninergic afferents in the trigeminal motor (Vm), facial (VII), and hypoglossal nuclei (XII) were studied in the rat by fluorescent retrograde labeling with Fluoro-Gold, in combination with immunofluorescence histochemistry for serotonin (5-HT). The results indicated: (1) The nucleus raphe magnus, nucleus raphe pallidus, and nucleus raphe obscurus contained 5-HT neurons projecting to the Vm, VII or XII. (2) The nucleus raphe dorsalis sends 5-HT fibres to the Vm and VII, but not to the XII. (3) The gigantocellular reticular nucleus pars alpha contained 5-HT neurons projecting to the VII.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afferent Pathways / cytology
  • Afferent Pathways / physiology
  • Animals
  • Cranial Nerves / cytology
  • Cranial Nerves / physiology*
  • Facial Nerve / cytology
  • Facial Nerve / physiology
  • Fluorescent Dyes
  • Hypoglossal Nerve / cytology
  • Hypoglossal Nerve / physiology
  • Immunoenzyme Techniques
  • Immunohistochemistry
  • Male
  • Neurons, Afferent / physiology*
  • Raphe Nuclei / physiology
  • Rats
  • Rats, Wistar
  • Reticular Formation / cytology
  • Reticular Formation / physiology
  • Serotonin / immunology
  • Serotonin / physiology*
  • Stilbamidines*
  • Trigeminal Ganglion / cytology
  • Trigeminal Ganglion / physiology

Substances

  • 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt
  • Fluorescent Dyes
  • Stilbamidines
  • Serotonin