Intracranial aneurysm formation following radiotherapy

Br J Neurosurg. 1993;7(5):575-9. doi: 10.3109/02688699308995083.


Two patients sustained a subarachnoid haemorrhage secondary to radiation-induced vasculopathy and associated aneurysm. A 65-year-old woman was treated by radiotherapy for a stereotactically biopsied left parieto-temporal astrocytoma. Three-and-a-half years later, she suffered a subarachnoid haemorrhage secondary to a giant aneurysm arising from the middle cerebral artery bifurcation. A 44-year-old man sustained a subarachnoid haemorrhage 21 years after receiving whole brain irradiation for a large left parietal angioma. Angiography following his subarachnoid haemorrhage revealed a distal right middle cerebral artery aneurysm that was not visible on earlier angiograms. Both patients underwent craniotomy for their aneurysms with good postoperative recoveries.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Astrocytoma / radiotherapy
  • Brain Neoplasms / radiotherapy
  • Cranial Irradiation / adverse effects*
  • Female
  • Hemangioma / radiotherapy
  • Humans
  • Intracranial Aneurysm / etiology*
  • Intracranial Aneurysm / surgery
  • Male
  • Radiation Injuries / etiology*
  • Radiation Injuries / surgery
  • Subarachnoid Hemorrhage / etiology
  • Subarachnoid Hemorrhage / surgery