Structure of toxic shock syndrome toxin 1

Biochemistry. 1993 Dec 21;32(50):13761-6. doi: 10.1021/bi00213a001.


The three-dimensional structure of toxic shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus has been determined and refined to an R value of 0.226 for data between 8- and 2.5-A resolution. Overall, the structure of TSST-1 is similar to that of another superantigen, staphylococcal enterotoxin B (SEB). The key differences between these molecules are in the amino termini and in the degree to which a long central helix is covered by surface loops. The region around the carboxyl end of this central helix is proposed to govern the superantigenic properties of TSST-1. An adjacent region along this helix is proposed to be critical in the ability of TSST-1 to induce toxic shock syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Antigens / immunology
  • Bacterial Toxins*
  • Enterotoxins / chemistry*
  • Enterotoxins / immunology
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation
  • Protein Conformation
  • Sequence Homology, Amino Acid
  • Staphylococcus aureus / chemistry*
  • Superantigens*


  • Antigens
  • Bacterial Toxins
  • Enterotoxins
  • Superantigens
  • enterotoxin F, Staphylococcal