Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein

Biochim Biophys Acta. 1993 Dec 14;1216(3):475-8. doi: 10.1016/0167-4781(93)90017-8.

Abstract

The cloning and sequencing of a cDNA for human ribosomal protein L4 is reported. The corresponding mRNA has a very short 5' untranslated region initiating with a sequence of 12 pyrimidines, characteristic of all vertebrate ribosomal protein mRNAs. The deduced amino acid sequence shows that human ribosomal protein L4 has 425 amino acid residues and a calculated molecular mass of 47,821 Da. Comparison with the homologous counterparts of Xenopus, Drosophila and yeast shows that this protein has a very conserved amino-terminus region and an extremely divergent carboxyl-terminus portion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / chemistry
  • DNA, Complementary / metabolism
  • Drosophila melanogaster / genetics
  • Humans
  • Molecular Sequence Data
  • Ribosomal Proteins / biosynthesis*
  • Ribosomal Proteins / genetics*
  • Saccharomyces cerevisiae / genetics
  • Sequence Homology, Amino Acid
  • Xenopus laevis

Substances

  • DNA, Complementary
  • Ribosomal Proteins
  • ribosomal protein L4

Associated data

  • GENBANK/L08443
  • GENBANK/S67477
  • GENBANK/S67478
  • GENBANK/S67479
  • GENBANK/S67480
  • GENBANK/S67481
  • GENBANK/S67526
  • GENBANK/S67527
  • GENBANK/S67530
  • GENBANK/X73974