Anti-tumor promoting activities of natural products. II. Inhibitory effects of digitoxin on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors

A Inada; T Nakanishi; T Konoshima; M Kozuka; H Tokuda; H Nishino; A Iwashima

doi:10.1248/bpb.16.930

Anti-tumor promoting activities of natural products. II. Inhibitory effects of digitoxin on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors

Biol Pharm Bull. 1993 Sep;16(9):930-1. doi: 10.1248/bpb.16.930.

Authors

A Inada¹, T Nakanishi, T Konoshima, M Kozuka, H Tokuda, H Nishino, A Iwashima

Affiliation

¹ Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.

PMID: 8268862
DOI: 10.1248/bpb.16.930

Abstract

Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), and mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide (4NQO) and glycerol, were inhibited by digitoxin (1).

MeSH terms

9,10-Dimethyl-1,2-benzanthracene / toxicity
Animals
Anticarcinogenic Agents / pharmacology*
Digitoxin / pharmacology*
Digitoxin / therapeutic use
Female
Glycerol / toxicity
Lung Neoplasms / chemically induced
Lung Neoplasms / prevention & control*
Mice
Papilloma / chemically induced
Papilloma / drug therapy*
Skin Neoplasms / chemically induced
Skin Neoplasms / prevention & control*
Tetradecanoylphorbol Acetate / toxicity

Substances

Anticarcinogenic Agents
9,10-Dimethyl-1,2-benzanthracene
Digitoxin
Tetradecanoylphorbol Acetate
Glycerol