Anti-tumor promoting activities of natural products. II. Inhibitory effects of digitoxin on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors

Biol Pharm Bull. 1993 Sep;16(9):930-1. doi: 10.1248/bpb.16.930.

Abstract

Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), and mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide (4NQO) and glycerol, were inhibited by digitoxin (1).

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Digitoxin / pharmacology*
  • Digitoxin / therapeutic use
  • Female
  • Glycerol / toxicity
  • Lung Neoplasms / chemically induced
  • Lung Neoplasms / prevention & control*
  • Mice
  • Papilloma / chemically induced
  • Papilloma / drug therapy*
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / prevention & control*
  • Tetradecanoylphorbol Acetate / toxicity

Substances

  • Anticarcinogenic Agents
  • 9,10-Dimethyl-1,2-benzanthracene
  • Digitoxin
  • Tetradecanoylphorbol Acetate
  • Glycerol