Relationship of IL-2, IL-2R (CD25+), soluble IL-2R and IL-4 with disease activity in SLE patients

Lupus. 1993 Aug;2(4):257-60. doi: 10.1177/096120339300200113.

Abstract

The plasma levels of interleukin-4 (IL-4), interleukin-2 (IL-2), soluble receptor of IL-2 (IL-2R) and T cell expression of IL-2 receptor chain (CD25+) were determined in an attempt to relate these parameters with disease activity in systemic lupus erythematosus (SLE). IL-4, IL-2 and sIL-2R plasma levels of SLE patients were significantly higher than those of the control group (P < 0.05) while CD25+ expression was similar in both groups. Only sIL-2R levels were significantly higher (P < 0.05) in active than in inactive patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Immunosuppression
  • Interleukin-2 / analysis
  • Interleukin-2 / blood*
  • Interleukin-4 / analysis
  • Interleukin-4 / blood*
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / epidemiology
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Prospective Studies
  • Receptors, Interleukin-2 / analysis*
  • Solubility
  • T-Lymphocytes / chemistry
  • T-Lymphocytes / pathology
  • T-Lymphocytes / ultrastructure

Substances

  • Interleukin-2
  • Receptors, Interleukin-2
  • Interleukin-4