Re-examination of some of the Framingham blood-pressure data

Lancet. 1978 Nov 25;2(8100):1139-41. doi: 10.1016/s0140-6736(78)92288-2.


Mathematical smoothing of data for the Framingham study leads to the conclusion that there is no threshold of normality for blood-pressure. A reasonable therapeutic goal might be "the lower the better". However, examination of the unsmoothed Framingham data indicates that while systolic pressures fit this no-threshold model reasonably well, changes in diastolic pressure below about 90 mm Hg have little or no prognostic significance. The poor fit of the diastolic points to the no-threshold model may also help to explain why at Framingham raised systolic pressure seemed to have a greater impact than raised diastolic pressure.

MeSH terms

  • Blood Pressure Determination / methods*
  • Blood Pressure*
  • Diastole
  • Female
  • Humans
  • Hypertension* / epidemiology
  • Hypertension* / mortality
  • Hypertension* / physiopathology
  • Male
  • Massachusetts
  • Mathematics
  • Prognosis
  • Regression Analysis
  • Systole