Psychiatric disorders in patients with Fabry's disease

Int J Psychiatry Med. 1993;23(3):307-12. doi: 10.2190/JKFW-3WXK-QA7N-BYLN.

Abstract

Objective: To determine the frequency and etiology of psychiatric complications in patients with Fabry's disease. Method-Retrospective analysis and review of the records of thirty-three patients with confirmed Fabry's disease.

Results: Six patients (18%) developed psychiatric disorders. Five patients suffered depression and two of these patients committed suicide. One patient developed an acute confusional episode with subsequent development of behavioral changes as a complication of cerebrovascular disease.

Conclusions: Psychiatric disorders, most commonly depression, complicate Fabry's disease and contribute to the morbidity and mortality of this disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carbamazepine / therapeutic use
  • Cerebrovascular Disorders / complications
  • Diplopia / complications
  • Fabry Disease / complications*
  • Fabry Disease / drug therapy
  • Fabry Disease / enzymology
  • Humans
  • Male
  • Mental Disorders / complications*
  • Pain
  • alpha-Galactosidase / blood
  • alpha-Galactosidase / metabolism

Substances

  • Carbamazepine
  • alpha-Galactosidase