Long-term disease-free survival in a child with refractory metastatic malignant germ cell tumor treated by high-dose chemotherapy with autologous bone marrow rescues

Med Pediatr Oncol. 1994;22(3):208-10. doi: 10.1002/mpo.2950220311.


We report the case of a 8-month-old girl who presented with a metastatic malignant germ cell tumor (MGCT) that proved to be resistant to chemotherapy, including salvage platinum-based combination therapy, surgery, and metastatectomy. The child was then treated with high-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow rescue (ABMR) for two courses, since the first course was well tolerated and resulted in serum alpha-f etoprotein normalisation. The child remains in complete remission 3 years post-ABMR and 4 years post-diagnosis, with no detectable treatment-related sequelae. Thus, as already reported in adults, dose-intensive chemotherapy with ABMR may have curative potential in children with refractory MGCT.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bone Marrow Transplantation*
  • Bone Neoplasms / secondary
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Drug Resistance
  • Female
  • Germinoma / secondary*
  • Germinoma / therapy*
  • Humans
  • Ifosfamide / administration & dosage
  • Infant
  • Liver Neoplasms / secondary
  • Neoplasm Recurrence, Local / therapy
  • Pelvic Neoplasms / pathology
  • Pelvic Neoplasms / therapy*
  • Recurrence
  • Remission Induction
  • Sacrococcygeal Region / pathology
  • Salvage Therapy*


  • Cisplatin
  • Ifosfamide