A subgroup of bipolar cells in human retina is GABA-immunoreactive

Neurosci Lett. 1993 Oct 29;161(2):187-90. doi: 10.1016/0304-3940(93)90290-2.


The distribution of GABA in the perifoveal and the near and far peripheral region of human retina was studied with peroxidase anti-peroxidase immunocytochemistry applied on semithin epoxy resin sections. Among the labeled amacrine cells in these regions, four types can be identified: putative diffuse A2 amacrines, stratified semilunar amacrines, interstitial amacrines and small displaced amacrines. GABA-immunoreactive interplexiform cells and ganglion cells also occur. Contrary to previous post-embedding studies, our preparations show that some bipolar cells in the near and far peripheral region are GABA-immunopositive. This indicates that a number of bipolar cells in human retina does have an enhanced GABA content.

MeSH terms

  • Eye Enucleation
  • Humans
  • Immunohistochemistry
  • Plastic Embedding
  • Retina / cytology
  • Retina / metabolism*
  • Retinal Ganglion Cells / metabolism
  • gamma-Aminobutyric Acid / immunology
  • gamma-Aminobutyric Acid / metabolism*


  • gamma-Aminobutyric Acid