Epidermal growth factor in the topical treatment of traumatic corneal ulcers

Ophthalmologica. 1993;206(3):119-24. doi: 10.1159/000310376.

Abstract

The tolerability and efficacy of epidermal growth factor (EGF) in the topical treatment of traumatic corneal ulcers have been evaluated in a double-blind, placebo-controlled, randomized study in two groups of patients. The time required for complete reepithelialization of the cornea was recorded, and the data obtained were analyzed statistically. In the EGF group the reepithelialization was significantly faster than in the control group. Tolerability of EGF was always excellent. These results indicate that EGF is safe and effective in reducing the healing time in the management of superficial corneal lesions.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Cornea / drug effects
  • Corneal Injuries*
  • Corneal Ulcer / drug therapy*
  • Corneal Ulcer / etiology
  • Double-Blind Method
  • Epidermal Growth Factor / administration & dosage*
  • Epidermal Growth Factor / therapeutic use
  • Epithelium / drug effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Wound Healing / drug effects

Substances

  • Ophthalmic Solutions
  • Epidermal Growth Factor