Effects of acute buprenorphine on responses to intranasal cocaine: a pilot study

Am J Drug Alcohol Abuse. 1993;19(4):451-64. doi: 10.3109/00952999309001634.


Five inpatients dependent on both intravenous cocaine and heroin were detoxified from opiates. They were then given 5 days of double-blind treatment with active or placebo buprenorphine 2 mg/d sublingually, followed by a crossover to the converse for 5 days (buprenorphine or placebo). Intranasal cocaine challenges (2 mg/kg) were performed on Days 3 and 5 of each treatment. Buprenorphine significantly enhanced patients' ratings of cocaine-induced pleasurable effects, and augmented cocaine-induced pulse increases. The buprenorphine enhancement of subjective cocaine effects appeared to be more prominent on Day 3 than on Day 5. This reduction from Day 3 to Day 5 suggests that cocaine may interact differently with buprenorphine as treatment is more prolonged.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Affect / drug effects
  • Arousal / drug effects*
  • Buprenorphine / therapeutic use*
  • Cocaine* / adverse effects
  • Comorbidity
  • Double-Blind Method
  • Drug Administration Schedule
  • Euphoria / drug effects
  • Female
  • Heroin Dependence / psychology
  • Heroin Dependence / rehabilitation*
  • Humans
  • Male
  • Pilot Projects
  • Substance Withdrawal Syndrome / psychology
  • Substance-Related Disorders / psychology
  • Substance-Related Disorders / rehabilitation*


  • Buprenorphine
  • Cocaine