Natural history of HLA expression during tumour development

Immunol Today. 1993 Oct;14(10):491-9. doi: 10.1016/0167-5699(93)90264-L.


HLA expression is frequently altered in tumours compared to the tissue from which they originate. Given the central role of MHC products in the restriction of T-cell recognition, regulation of tumour HLA expression might be a strategy for the evasion of immune surveillance by the malignant cells. Federico Garrido, Peter Stern and colleagues present data from a variety of tumour types, suggesting that HLA class I alterations may occur at a particular step between the development of an in situ lesion and an invasive carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma in Situ / immunology
  • Female
  • Gene Expression
  • HLA Antigens / genetics
  • HLA Antigens / metabolism*
  • Humans
  • Models, Biological
  • Neoplasm Invasiveness / immunology
  • Neoplasms / etiology*
  • Neoplasms / immunology
  • Precancerous Conditions / immunology


  • HLA Antigens