Role of heparan sulfate in immune system-blood vessel interactions

Immunol Today. 1993 Oct;14(10):500-5. doi: 10.1016/0167-5699(93)90265-M.


Heparan sulfate proteoglycan, a component of endothelial cell membranes and extracellular matrices, is involved in a number of the critical functions of endothelium and of antigen-presenting cells. This review discusses how heparan sulfate is released from endothelial cells during inflammation, how the loss of heparan sulfate potentially alters endothelial cell physiology, and how the presence of heparan sulfate in a soluble form might regulate the functioning of lymphocytes at sites of inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Blood Vessels / immunology*
  • Endothelium, Vascular / immunology
  • Heparan Sulfate Proteoglycans
  • Heparitin Sulfate / immunology*
  • Humans
  • Models, Biological
  • Proteoglycans / immunology


  • Heparan Sulfate Proteoglycans
  • Proteoglycans
  • Heparitin Sulfate