This review looks at the magnetoencephalogram (MEG) studies on generalized epilepsy starting from the first cases investigated up to the most recent contributions regarding the photoconvulsive response and the results obtained applying the template analysis. As far as the spike-and-wave complex is concerned, in the cases both of photoconvulsive response and of non-generalized epilepsy, a primary multiregional participation of the cerebral cortex is shown, which, variable in time and often with a side prevalence, is alternated by bisynchronous epileptiform activity starting from midline structures.