Failure to induce long-term depression by an anti-correlation procedure in area CA1 of the rat hippocampal slice

Eur J Neurosci. 1993 Oct 1;5(10):1241-6. doi: 10.1111/j.1460-9568.1993.tb00909.x.


We have independently in our two laboratories re-examined the report by Stanton and Sejnowski (Nature, 339, 215-218, 1989) that single stimuli to a test pathway in area CA1 of the hippocampal slice, when delivered between short bursts of stimuli to a second, convergent pathway, produce an associative long-term depression (LTD) in the test pathway. While robust associative LTP was observed when stimuli to the two inputs were correlated in time, the anti-correlation procedure failed to induce LTD; rather, a trend towards potentiation was observed. This result was obtained using both submerged and interface chambers, and in two different strains of rat. A transient depression lasting for a few minutes could usually be elicited by strong tetanic stimulation; this depression was not restricted to activated pathways.

MeSH terms

  • Animals
  • Electric Stimulation
  • Evoked Potentials
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Long-Term Potentiation*
  • Male
  • Models, Neurological
  • Neurons / physiology*
  • Rats
  • Rats, Wistar
  • Synapses / physiology
  • Time Factors