Prenatal Cocaine Exposure: Increased Striatal Dopamine Transporter Binding in Offspring at 3 and 6 Months of Age

Brain Res Bull. 1994;33(2):223-4. doi: 10.1016/0361-9230(94)90256-9.


Prior studies indicate that prenatal cocaine exposure can alter dopamine transporter binding in mature mice. To determine the persistence of these effects, pregnant mice were treated with cocaine, 10 mg/kg/d, during days 13 to 20 of gestation and dopamine transporter binding was evaluated in offspring at 3 and 6 months of age. In contrast to prior studies, binding in striatum was significantly increased at both time points in cocaine-exposed mice compared to controls.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Carrier Proteins / drug effects*
  • Carrier Proteins / metabolism*
  • Cocaine / pharmacology*
  • Corpus Striatum / drug effects*
  • Corpus Striatum / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Female
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Mice
  • Nerve Tissue Proteins*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*


  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Cocaine