Cytogenetic studies of epithelial ovarian carcinoma

Cancer Genet Cytogenet. 1993 Nov;71(1):76-86. doi: 10.1016/0165-4608(93)90205-z.


We performed cytogenetic studies of 36 human epithelial ovarian carcinomas using in situ culture and robotic harvest. We obtained analyzable metaphases of all 36 tumors (100%). One or more chromosomally abnormal clones were observed in 80% of tumors. Common clonal chromosome gains (each occurring in six or more cases) included +1, +2, +3, +6, +7, +9, and +12. Common clonal chromosome losses (occurring in 12 or more cases) included -X, -4, -8, -11, -13, -15, -17, and -22. Common clonal structural abnormalities (occurring in four or more cases) involved regions 1p36, 1q32, 1q42, 3p13-->p26, 3q26-->q29, 7p22, 9q34, 11p13-p15, 17q21-->q23, 19p13.3, and 19q13.3. Trisomy 12 was noted as the sole anomaly in three of five borderline and grade 1 tumors. Two grade 2 tumors contained i(1q), -14, -15 and -22. The results suggest that the pathogenesis of borderline and low-grade tumors may differ from that of higher grade tumors. Two high-grade tumors had an apparent translocation between 17q21 and 19p13.3, two chromosome regions believed to be critical to ovarian carcinogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma, Clear Cell / genetics
  • Adenocarcinoma, Mucinous / genetics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Endometrioid / genetics
  • Chromosome Aberrations*
  • Cystadenocarcinoma, Serous / genetics
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / genetics*