Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol

Chest. 1994 Jan;105(1):106-10. doi: 10.1378/chest.105.1.106.


A study of 18 different commercially available continuous-flow, jet nebulizers was performed with a standard liposomal formulation of beclomethasone dipropionate (Bec-DP) prepared with dilauroyl phosphatidylcholine (Bec-DLPC). The analysis compared the total Bec-DP output from aqueous suspensions of Bec-DLPC containing an initial starting reservoir concentration of 0.5 mg/ml. Aerosols from each nebulizer tested were characterized by the mass median aerodynamic diameter, geometric standard deviation, drug output, and the predicted percentage regional deposition of inhaled Bec-DLPC liposomes within the human respiratory tract. These data can provide a basis for the selection of commercially available jet nebulizers for use with glucocorticoid liposome aerosols for treatment of asthma and other inflammatory lung diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerosols
  • Beclomethasone / administration & dosage*
  • Beclomethasone / analysis
  • Beclomethasone / chemistry
  • Beclomethasone / pharmacokinetics
  • Chromatography, High Pressure Liquid
  • Drug Carriers
  • Equipment Design
  • Humans
  • Liposomes
  • Lung / metabolism
  • Models, Biological
  • Mouth Breathing
  • Nebulizers and Vaporizers*
  • Particle Size
  • Phosphatidylcholines / administration & dosage
  • Phosphatidylcholines / analysis
  • Phosphatidylcholines / chemistry
  • Phosphatidylcholines / pharmacokinetics
  • Pulmonary Ventilation
  • Residual Volume
  • Surface Properties
  • Tidal Volume


  • Aerosols
  • Drug Carriers
  • Liposomes
  • Phosphatidylcholines
  • 1,2-dilauroylphosphatidylcholine
  • Beclomethasone