The isochore organization of the human genome and its evolutionary history--a review

Gene. 1993 Dec 15;135(1-2):57-66. doi: 10.1016/0378-1119(93)90049-9.


This review will first present some properties (including compositional pattern, correlations between isochores and chromosomal bands, and gene distribution) of the human genome, the most extensively studied among vertebrate genomes. It will then explain how these properties came about during the evolution of the vertebrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Evolution*
  • Genome, Human*
  • Humans