Two new cytotoxic chalcones from Calythropsis aurea

J A Beutler; J H Cardellina 2nd; G N Gray; T R Prather; R H Shoemaker; M R Boyd; C M Lin; E Hamel; G M Cragg

doi:10.1021/np50100a009

Two new cytotoxic chalcones from Calythropsis aurea

J Nat Prod. 1993 Oct;56(10):1718-22. doi: 10.1021/np50100a009.

Authors

J A Beutler¹, J H Cardellina 2nd, G N Gray, T R Prather, R H Shoemaker, M R Boyd, C M Lin, E Hamel, G M Cragg

Affiliation

¹ Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, Maryland 21702-1201.

PMID: 8277311
DOI: 10.1021/np50100a009

Abstract

The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Chalcone / analogs & derivatives*
Chalcone / isolation & purification
Chalcone / pharmacology
Drug Screening Assays, Antitumor
Humans
Leukemia L1210 / drug therapy
Mitosis / drug effects
Plant Extracts / analysis
Plants, Medicinal / chemistry*
Propiophenones / isolation & purification*
Propiophenones / pharmacology
Tubulin / metabolism
Western Australia

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Propiophenones
Tubulin
dihydrocalythropsin
calythropsin
Chalcone