Combined local excision and brachytherapy with ruthenium-106 in the treatment of epibulbar malignancies

Ophthalmologica. 1993;207(3):133-9. doi: 10.1159/000310419.


Two patients with epibulbar malignancies were treated by local excision and brachytherapy with ruthenium-106. One patient showed a large melanoma on the epibulbar conjunctiva, the other patient suffered from a recurrent squamous cell carcinoma at the limbus. After excision of the tumor including lamellar sclerectomy and keratectomy, a ruthenium-106 plaque was sutured to the sclera, and a total dose of 290 and 320 Gy, respectively, was delivered to the tumor bed. No severe radiogenic complications were observed except for a rarefaction of the sclera in the treatment area and a slow cataract increase. After a follow-up period of 50 and 22 months, respectively, both patients do not show any recurrence or metastatic disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brachytherapy*
  • Carcinoma, Squamous Cell / radiotherapy*
  • Carcinoma, Squamous Cell / surgery*
  • Combined Modality Therapy
  • Conjunctival Neoplasms / radiotherapy*
  • Conjunctival Neoplasms / surgery*
  • Corneal Diseases / radiotherapy
  • Corneal Diseases / surgery
  • Eye Diseases / radiotherapy
  • Eye Diseases / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Melanoma / radiotherapy*
  • Melanoma / surgery*
  • Middle Aged
  • Neoplasm Invasiveness
  • Ruthenium Radioisotopes / therapeutic use*


  • Ruthenium Radioisotopes