Corneoscleral ulceration and corneal perforation after pterygium excision and topical mitomycin C therapy

Ophthalmologica. 1993;207(3):162-4. doi: 10.1159/000310424.


A 78-year-old woman complained of ocular pain in the right eye. Thirty-three months before, the patient had a pterygium excised and mitomycin C, 0.04%, was instilled 3 times a day postoperatively for 10 days in the right eye. The same surgery was performed and the same drug was used for a course of 5 days in the left eye. Corneoscleral ulceration and corneal performation occurred in the right eye. The lesions were successfully treated with a lamellar patch graft with reserved corneosclera. We believe that it may not be safe to instill 0.04% mitomycin C 3 times a day postoperatively for 10 days.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Aged
  • Corneal Ulcer / chemically induced*
  • Corneal Ulcer / surgery
  • Female
  • Humans
  • Mitomycin / administration & dosage
  • Mitomycin / adverse effects*
  • Ophthalmic Solutions
  • Postoperative Complications*
  • Pterygium / drug therapy
  • Pterygium / surgery*
  • Scleral Diseases / chemically induced*
  • Scleral Diseases / surgery
  • Ulcer / chemically induced
  • Ulcer / surgery


  • Ophthalmic Solutions
  • Mitomycin