Prenatal cystic fibrosis carrier screening: factors in a woman's decision to decline testing

Prenat Diagn. 1993 Sep;13(9):807-14. doi: 10.1002/pd.1970130904.


Among 2207 women eligible to be screened for cystic fibrosis (CF) carrier status during pregnancy, 325 (15 per cent) declined to be tested. Of these, 260 (80 per cent) answered a questionnaire soliciting their reasons for not participating. The main factor was opposition to termination of pregnancy, with 43 per cent being against termination for any reason and another 11 per cent against termination of a CF fetus. Other reasons given were partner's disapproval or non-participation (10 per cent), perceived risk of a CF child being low (7 per cent), the error rate of the test (6 per cent), and the generation of unacceptable levels of anxiety (5 per cent). Eleven women (4 per cent) said that they did not wish to be tested during pregnancy, but only six of these would have accepted screening at another time.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Therapeutic / psychology
  • Adolescent
  • Adult
  • Chi-Square Distribution
  • Cystic Fibrosis / diagnosis*
  • Cystic Fibrosis / psychology
  • Female
  • Genetic Carrier Screening*
  • Genetic Testing / psychology*
  • Humans
  • Pregnancy
  • Pregnant Women*
  • Prenatal Diagnosis / psychology*
  • Surveys and Questionnaires
  • Treatment Refusal / psychology*
  • Voluntary Programs