Abstract
The mutagenicity of N,N-dimethyl-4-aminoazobenzene and N-methyl-4-aminoazobenzene and their derivatives was shown on Salmonella typhimurium TA100 and TA98. S-9 Mix, obtained from rat liver after injection of polychlorinated biphenyl, was abligatory for their mutagenic action. N-Acetoxy-N-methyl-4-aminoazobenzene and N-benzoyloxy-N-methyl-4-aminoazobenzene and their 4'-methoxycarbonyl derivatives were also mutagenic on TA100 and TA98 and did not require metabolic activation by S-9 Mix. It is suggested that the carcinogenic effects of azo dyes may involve modification of DNA.
MeSH terms
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Animals
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Azo Compounds / metabolism
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Azo Compounds / pharmacology*
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Dose-Response Relationship, Drug
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In Vitro Techniques
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Microsomes, Liver / metabolism
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Mutagens*
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Rats
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Salmonella typhimurium / drug effects
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o-Aminoazotoluene / pharmacology
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p-Aminoazobenzene / analogs & derivatives
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p-Aminoazobenzene / pharmacology
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p-Dimethylaminoazobenzene / administration & dosage
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p-Dimethylaminoazobenzene / analogs & derivatives*
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p-Dimethylaminoazobenzene / metabolism
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p-Dimethylaminoazobenzene / pharmacology*
Substances
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Azo Compounds
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Mutagens
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p-Aminoazobenzene
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p-Dimethylaminoazobenzene
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o-Aminoazotoluene