Mild de Lange syndrome--does it exist?

Clin Dysmorphol. 1993 Apr;2(2):147-50.


A pair of mildly retarded, microcephalic twins (probably identical) are reported. They were initially diagnosed as having the de Lange syndrome on the basis of the synophrys, but, on follow-up, their main intellectual defect was in the area of expressive speech. It is suggested that the evidence in the literature for the existence of so-called mild de Lange is sparse and that the twins in this report might well have a different, possibly unique condition.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • De Lange Syndrome / diagnosis*
  • Diseases in Twins / diagnosis
  • Humans
  • Intellectual Disability / diagnosis
  • Male
  • Mental Disorders / diagnosis
  • Speech Disorders / diagnosis