A new approach in the diagnosis and follow-up of bladder cancer. FISH analysis of urine, bladder washings, and tumors

Cancer Genet Cytogenet. 1993 Dec;71(2):105-18. doi: 10.1016/0165-4608(93)90015-e.


The aim of the present study was to ascertain whether fluorescence in situ hybridization (FISH) of urine could be a useful approach in bladder cancer. Herein, we present the cytogenetic and FISH findings in patients with and without bladder cancer. The samples examined with FISH consisted of urine, bladder washings, and tumor tissue, when available. The results obtained show that the FISH technique, particularly when used on urine, is a very useful tool in the diagnosis, early detection, and management of bladder cancer.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aneuploidy
  • Carcinoma in Situ / diagnosis
  • Carcinoma in Situ / genetics
  • Carcinoma in Situ / urine
  • Carcinoma, Transitional Cell / diagnosis*
  • Carcinoma, Transitional Cell / genetics
  • Carcinoma, Transitional Cell / urine
  • Centromere
  • Chromosome Aberrations
  • DNA Probes
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Karyotyping
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / urine
  • Sensitivity and Specificity
  • Therapeutic Irrigation
  • Urinalysis / methods*
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / urine
  • Urine / cytology


  • DNA Probes