Ten sexually functional and 10 dysfunctional men viewed sexually explicit films following ingestion of each of three placebo pills described as an erection enhancement pill, an erection detraction pill, and a placebo pill. Functionals evidenced a reverse placebo effect with significantly higher erectile response under the detraction relative to the enhancement and placebo conditions. Dysfunctionals evidenced a direct placebo effect with significantly lower erectile response under the detraction relative to the enhancement and placebo conditions. Fifteen Ss (75%) responded according to group patterns. Results suggest yet another arena in which functional and dysfunctional men respond in a fundamentally different manner. This pattern of differential responding may be due to relative differences in level of interoceptive awareness and/or interoceptive avoidance between functional and dysfunctional Ss and reflect on the nature of anxiety.