Oncogenes, tumor suppressors and viruses in oral squamous carcinoma

J Oral Pathol Med. 1993 Sep;22(8):337-47. doi: 10.1111/j.1600-0714.1993.tb01086.x.


The pathogenesis of oral squamous cell carcinoma involves recognised carcinogens in tobacco and/or alcohol but other factors, including viruses, may also have a role. This paper reviews the gene changes revealed in oral carcinoma, the evidence implicating viruses, and mechanisms whereby viruses may affect gene function.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / microbiology*
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Neoplastic / physiology
  • Genes, Tumor Suppressor / genetics*
  • Humans
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / microbiology*
  • Oncogenes / genetics*
  • Oncogenic Viruses / genetics
  • Oncogenic Viruses / physiology*