Improved contrast of enhancing brain lesions on postgadolinium, T1-weighted spin-echo images with use of magnetization transfer

Radiology. 1994 Feb;190(2):553-9. doi: 10.1148/radiology.190.2.8284415.


Purpose: To prove that the contrast of enhancing brain lesions on post-gadolinium T1-weighted spin-echo (SE) images can be statistically significantly improved with magnetization-transfer (MT) indirect saturation.

Materials and methods: The contrast-to-noise ratios (C/Ns) of 201 enhancing brain lesions in 110 patients were compared on conventional and MT T1-weighted SE images obtained at 1.5 T after injection of 0.05-0.10 mmol/kg gadopentetate dimeglumine or gadodiamide.

Results: The MT T1-weighted SE images showed a 37% reduction in signal intensity of background white matter and thereby provided a 108% improvement in the C/N of enhancing brain lesions over the conventional T1-weighted SE images (P < .001).

Conclusion: The C/Ns obtained with single-dose gadolinium and the MT T1-weighted SE technique were twice those obtained with the conventional technique and are at least equivalent to reported values obtained with triple-dose gadolinium and conventional T1-weighted SE images.

Publication types

  • Comparative Study

MeSH terms

  • Brain / pathology
  • Brain Diseases / diagnosis*
  • Contrast Media*
  • Drug Combinations
  • Gadolinium DTPA
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / methods*
  • Meglumine*
  • Organometallic Compounds*
  • Pentetic Acid / analogs & derivatives*


  • Contrast Media
  • Drug Combinations
  • Organometallic Compounds
  • Meglumine
  • Pentetic Acid
  • gadodiamide
  • Gadolinium DTPA