Congenital Horner's syndrome does not alter Lisch nodule formation

Ann Neurol. 1994 Jan;35(1):123-4. doi: 10.1002/ana.410350121.


A 21-year-old woman with neurofibromatosis type 1 (NF-1) had a unilateral congenital Horner's syndrome with resultant hypopigmentation of the affected iris. Lisch nodules, which are melanocytic hamartomas, were similar in number, size, and pigmentation in both eyes. The present findings suggest that the formation of Lisch nodules is not influenced by the presence or absence of sympathetic innervation of the iris.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Hamartoma / complications
  • Hamartoma / physiopathology*
  • Horner Syndrome / complications
  • Horner Syndrome / congenital*
  • Horner Syndrome / physiopathology
  • Humans
  • Iris Diseases / complications
  • Iris Diseases / physiopathology*
  • Neurofibromatosis 1 / complications
  • Neurofibromatosis 1 / physiopathology*