Permanent indwelling intravenous devices (PIIDs) have become increasingly prevalent in the past decade. These devices offer the advantage of long-term and convenient venous access, but their not-infrequent colonization by bacterial or fungi can lead to bloodstream infection with or without sepsis. We describe a series of four patients with PIIDs who became infected with Pseudomonas pickettii, and we review the properties of this unusual organism and the clinical presentation of the infections it causes.