Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats

Cardiovasc Res. 1993 Sep;27(9):1619-23. doi: 10.1093/cvr/27.9.1619.


Objective: The aim was to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) in monocrotaline induced pulmonary hypertension.

Methods: Plasma 5-HT levels, pulmonary capillary platelet count, and vascular responsiveness to 5-HT were evaluated in the model. The effects of the selective 5-HT2 receptor antagonist, DV-7028, on the development of pulmonary hypertension were also investigated.

Results: Plasma 5-HT was raised 12 h to 3 d after monocrotaline administration (60, coinciding with accumulation of platelets in the pulmonary circulation. Isolated pulmonary arteries showed hyperreactivity to 5-HT at 14 and 21 d after monocrotaline. Administration of DV-7028 (20 x d-1) attenuated the increase in pulmonary arterial pressure, right ventricular hypertrophy, and medial thickening of the pulmonary arteries.

Conclusions: The present study suggests that 5-HT released from platelets contributes to the initiation and progression of monocrotaline induced pulmonary hypertension.

MeSH terms

  • Animals
  • Blood Platelets / ultrastructure
  • Culture Techniques
  • Hypertension, Pulmonary / blood
  • Hypertension, Pulmonary / chemically induced*
  • Hypertension, Pulmonary / pathology
  • Lung / ultrastructure
  • Male
  • Monocrotaline / toxicity*
  • Piperidines / pharmacology
  • Platelet Count
  • Pulmonary Artery / drug effects
  • Rats
  • Serotonin / blood
  • Serotonin / pharmacology
  • Serotonin / physiology*
  • Serotonin Antagonists / pharmacology
  • Triazines / pharmacology


  • Piperidines
  • Serotonin Antagonists
  • Triazines
  • DV 7028
  • Serotonin
  • Monocrotaline