Analysis of the Salmonella Fim Gene Cluster: Identification of a New Gene (fimI) Encoding a Fimbrin-Like Protein and Located Downstream From the fimA Gene

FEMS Microbiol Lett. 1993 Dec 15;114(3):259-65. doi: 10.1111/j.1574-6968.1993.tb06583.x.

Abstract

The fimA gene coding for the major component (fimbrin) of type 1 fimbriae was mapped within the Salmonella typhi fim gene cluster, and its nucleotide sequence determined. The deduced amino acid sequence of S. typhi fimbrin is highly homologous to that of S. typhimurium type 1 fimbrin and showed similarity to that of other enterobacterial type 1 fimbrins. Downstream of fimA, an open reading frame was found, named fimI, able to encode a fimbrin-like protein. The fimI product could represent the counterpart, in type 1 fimbriae, of the PapH protein involved in cell anchoring and length modulation of Escherichia coli Pap pili. This genetic organization was found to be common to other Salmonella serovars, including S. typhimurium and S. choleraesuis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Genes, Bacterial / genetics*
  • Membrane Glycoproteins / genetics*
  • Microfilament Proteins*
  • Molecular Sequence Data
  • Multigene Family
  • Salmonella typhi / genetics*
  • Salmonella typhimurium / genetics*
  • Sequence Homology, Amino Acid
  • Species Specificity

Substances

  • Membrane Glycoproteins
  • Microfilament Proteins
  • plastin

Associated data

  • GENBANK/X65168
  • GENBANK/X74064
  • GENBANK/X74065