New antidepressants and the treatment of depression

J Fam Pract. 1994 Jan;38(1):49-57.


Depression is a common and significant health problem associated with impairment in a patient's ability to function. The development of new antidepressant medications represents progress in its treatment. These new agents work through the selective blockade of the reuptake of serotonin into the presynaptic neuron, thereby increasing the availability of this neurotransmitter at the synaptic cleft and enhancing its effectiveness. While no more effective than traditional tricyclic antidepressant drugs, the new agents are generally safer than traditional medications used to treat depression: they are well tolerated and, in case of overdose, less harmful than tricyclic antidepressants.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antidepressive Agents, Tricyclic / therapeutic use
  • Contraindications
  • Depressive Disorder / drug therapy*
  • Humans
  • Serotonin Uptake Inhibitors / pharmacology
  • Serotonin Uptake Inhibitors / therapeutic use*


  • Antidepressive Agents, Tricyclic
  • Serotonin Uptake Inhibitors