Hereditary nephrogenic diabetes insipidus and bilateral nonobstructive hydronephrosis

Nephron. 1993;65(3):346-9. doi: 10.1159/000187510.


We describe 2 cases of hereditary nephrogenic diabetes insipidus with massive bilateral dilatation of the urinary tract without any organic obstruction. A review of the literature revealed that dilatation of the urinary tract was present in 67% of the reported cases of nephrogenic diabetes insipidus which included a description of the urinary tract. This strong association between hereditary nephrogenic diabetes insipidus and nonobstructive hydronephrosis suggests a cause-and-effect relationship in which polyuria is responsible for the hydronephrosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Diabetes Insipidus / complications*
  • Diabetes Insipidus / diagnosis
  • Diabetes Insipidus / genetics*
  • Dilatation, Pathologic
  • Humans
  • Hydronephrosis / etiology*
  • Hydronephrosis / pathology
  • Male
  • Polyuria / complications
  • Urinary Tract / pathology