A controlled comparison of the effects of propranolol, benztropine, and placebo on akathisia: an interim analysis

Psychopharmacol Bull. 1993;29(2):283-6.


A group of 28 patients was treated to compare the effects on akathisia of the following: propranolol (80 mg/day), benztropine (6 mg/day), or placebo. Both propranolol and benztropine significantly improved akathisia by Day 3-5 of treatment. Placebo had no significant effects of akathisia. Three patients developed confusion or forgetfulness by Day 3 of benztropine treatment; these effects cleared upon discontinuation of benztropine.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Akathisia, Drug-Induced / drug therapy*
  • Benztropine / adverse effects
  • Benztropine / therapeutic use*
  • Humans
  • Middle Aged
  • Propranolol / adverse effects
  • Propranolol / therapeutic use*
  • Single-Blind Method


  • Benztropine
  • Propranolol