DNA damage and the DNA-activated protein kinase

Trends Biochem Sci. 1993 Nov;18(11):433-7. doi: 10.1016/0968-0004(93)90144-c.

Abstract

DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that is activated in vitro by DNA fragments. The cellular targets of DNA-PK are nuclear, DNA-binding, regulatory proteins including Sp1, Fos, Jun, Myc, the tumor suppressor protein p53, and RNA polymerase II. These characteristics suggest a role for DNA-PK in coordinating nuclear processes and as a modulator of checkpoint mechanisms activated by DNA damage.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA Damage / physiology*
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / physiology*
  • Substrate Specificity

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Peptides
  • DNA-Activated Protein Kinase
  • PRKDC protein, human
  • Protein-Serine-Threonine Kinases