Osteoporosis is a disease that characteristically afflicts postmenopausal women. It is estimated that millions of people are plagued yearly with this debilitating disease. Associated health care costs are in the billions of dollars, annually. Much research has been conducted in the area of osteoporosis and mineral supplementation, mainly focusing on calcium and vitamin D. Nonetheless, more recent studies have reported possible improvements in bone mineral density in women who were supplemented with the ultratrace mineral, boron. Boron may play a role in bone metabolism, but its role is most likely to be associated with its interactions with other minerals and vitamins such as calcium, magnesium and vitamin D. Although the focus of this review will be to discuss the interactive role of boron with magnesium and bone metabolism, some discussion of its interactive role with vitamin D is also necessary.