New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis

Int J Exp Pathol. 1993 Dec;74(6):627-34.

Abstract

Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.

MeSH terms

  • Acute Disease
  • Aging
  • Animals
  • Bone and Bones / pathology
  • Cartilage, Articular / pathology
  • Chronic Disease
  • Disease Models, Animal*
  • Extremities
  • Joints / pathology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Osteoarthritis / pathology*
  • Pilot Projects
  • Synovial Membrane / pathology
  • Synovitis / pathology