[Study of diffusion weighted magnetic resonance imaging in Wilson's disease]

Rinsho Shinkeigaku. 1993 Oct;33(10):1086-9.
[Article in Japanese]


We analyzed diffusion weighted magnetic resonance images (diffusion MRI) of the basal ganglia, which were obtained from four patients with Wilson's disease, and compared them with the images from ten age-matched normal individuals. In all patients, T2-MRI of the basal ganglia disclosed low or iso-signals, but diffusion MRI revealed abnormal high signals in some areas of the basal ganglia in each case. Pathological changes except for copper and/or iron deposits are difficult to estimate by T2-MRI because the low signal on T2-MRI emphatically reflects the deposits, while the abnormal high signal on diffusion MRI is thought to reflect parenchymal lesions such as cell loss, demyelination and/or increase of the extracellular fluid. From our results, we confirmed that diffusion MRI was very useful for estimating parenchymal lesions with metal deposits.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Basal Ganglia / pathology*
  • Female
  • Hepatolenticular Degeneration / diagnosis*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male