Comparative study: Replens versus local estrogen in menopausal women

Fertil Steril. 1994 Jan;61(1):178-80. doi: 10.1016/s0015-0282(16)56474-7.


This was an open-label study comparing effects of a nonhormonal drug-free bioadhesive vaginal moisturizer to a local estrogen therapy in the treatment of vaginal dryness symptoms. There were 15 women evaluated in each treatment group during a 12-week period. Results indicated that the bioadhesive vaginal moisturizer was a safe and effective alternative to estrogen vaginal cream, with both therapies exhibiting statistically significant increases in vaginal moisture, vaginal fluid volume, and vaginal elasticity with a return of the premenopausal pH state.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Estrogen Replacement Therapy / methods*
  • Estrogens, Conjugated (USP) / administration & dosage
  • Estrogens, Conjugated (USP) / pharmacology
  • Estrogens, Conjugated (USP) / therapeutic use*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Lipids
  • Menopause*
  • Middle Aged
  • Vagina / drug effects*
  • Vagina / metabolism
  • Vagina / pathology
  • Vaginal Creams, Foams, and Jellies / pharmacology
  • Vaginal Creams, Foams, and Jellies / therapeutic use*
  • Vaginal Diseases / drug therapy*
  • Vaginal Smears


  • Estrogens, Conjugated (USP)
  • Lipids
  • Replens
  • Vaginal Creams, Foams, and Jellies