A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

Gene. 1993 Dec 22;136(1-2):355-60. doi: 10.1016/0378-1119(93)90495-o.


We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluorescence in situ hybridization (FISH) sublocalized APJ on band q12.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cells, Cultured
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Cloning, Molecular
  • DNA
  • Humans
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Receptors, Angiotensin / genetics*
  • Sequence Homology, Amino Acid
  • Species Specificity


  • Receptors, Angiotensin
  • DNA

Associated data

  • GENBANK/D17345
  • GENBANK/D17346
  • GENBANK/D17347
  • GENBANK/D17348
  • GENBANK/D17349
  • GENBANK/L24529
  • GENBANK/U03642
  • GENBANK/X72989
  • GENBANK/Z15047
  • GENBANK/Z15048