Cocaine Enhancement of the Action of 5-hydroxytryptamine in Rat Cingulate Cortex in Vitro

Neurosci Lett. 1993 Nov 26;163(1):50-2. doi: 10.1016/0304-3940(93)90226-b.


Intracellular recordings were made in vitro from pyramidal neurons in layer V of the anterior cingulate cortex of the rat. 5-Hydroxytryptamine (5-HT) reduced the amplitude of the excitatory postsynaptic potential; receptor-selective agonists and antagonists indicated that this resulted from activation of the 5-HT1B receptor. The action of 5-HT was enhanced by cocaine (300 nM-3 microM); 1 microM cocaine increased sensitivity to 5-HT about 10-fold. The results suggest that cocaine is similarly effective to potentiate the action of 5-HT in the prefrontal cortex as in other brain regions. This may contribute to its overall in vivo effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cocaine / pharmacology*
  • Dopamine / pharmacology
  • Drug Synergism
  • Electrophysiology
  • Evoked Potentials / drug effects
  • Prefrontal Cortex / drug effects*
  • Pyramidal Cells / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Serotonin / drug effects
  • Serotonin / pharmacology*
  • Serotonin Antagonists
  • Serotonin Receptor Agonists / pharmacology
  • Synapses / drug effects


  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Serotonin
  • Cocaine
  • Dopamine