This paper describes 90 cases of Buruli ulcer in Amansie West district, Ghana. 49% were below 15 years of age while 20% were over 50 years. There was a significant difference in the age and sex composition, with more males among the younger age groups than females but the converse among adults. Seasonal variation is described, with peak incidence in September and October. Cases who had received bacillus Calmette-Guérin (BCG) vaccination had a shorter duration of the ulcer than those who were not vaccinated. No such association was found between BCG vaccination and the age of onset of the disease. There was no significant difference between cases and controls regarding their BCG vaccination status. There is an urgent need to regard Buruli ulcer in Ghana more seriously.